Congenital syphilis-
Symptomatic neonate, neonate with congenital syphilis: 50,000 U/kg IV q 12 h × 1st 7 day of life, then q 8 h × 3 day to total 10 day.
Untreated congenital syphilis-
Infant: 50,000 U/kg IV q 4-6 h × 10-14 day.
Systemic infection-
Neonate < 1 wk and 1.2-2 kg: 25,000 U IM, IV q 12 h.
Neonate < 1 wk and > 2 kg: 25,000 U IM, IV q 8 h.
Neonate 1-4 wk and 1.2-2 kg: 25,000 U IM, IV q 8 h.
Neonate 1-4 wk and > 2 kg: 25,000 U IM, IV q 6 h.
Neonate = 4 wk and < 1.2 kg: 25,000 U IM, IV q 12 h.
Infant, child = 1 month: 25,000-50,000 U/kg qd IM or IV in 4 divided doses.
Severe infection: 250,000-400,000 U/kg IM, IV qd in divided doses q 4-6 h.
Child = 12 yr, adult: 5-15 million U IM, IV qd in divided doses q 4 h.
Meningitis caused by group B streptococci-
Neonate < 1 wk: 250,000-450,000 U/kg IV qd in 3 divided doses.
Neonate > 1 wk: 450,000 U/kg IV qd in 4 divided doses.
Infant, child = 1 month: 250,000-400,000 U/kg IV qd in divided doses q 4-6 h. |